Tsholotsho is home to three ethnic groups, these being the Ndebele, Kalanga (along the Manzamnyama river) and the San (closer to the Hwange national park.The principal language is Ndebele which is spoken and understood by practically everyone in the district.

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Tsholotsho District is an administrative district in Matabeleland North Province, Zimbabwe. Its administrative centre is the business service centre of Tsholotsho which is located about 65 km north-west of Nyamandhlovu and 98 km north-west of Bulawayo as the bald eagle flies, in the Tsholotsho communal land. Districts around Tsholotsho include Lupane, Hwange, Umguza, and Bulilimamangwe District.

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Tsholotsho is home to hardwoods such as teak, these being found in the Kalahari sands. The clays are home to the thorn acacia and extensively covered grassland areas. Being located next to the massive Hwange National Park, Tsholotsho is home to basically all the animal species found in Zimbabwe, these being the elephants, buffaloes, lions, kudus and hundreds of other species.

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